The Museo de los Orishas is managed by the Asociación Cultural Yoruba de Cuba. The museum is dedicated to Santería (worship of saints) that is an Afro-American religion of Yoruba origin, developed in Cuba among descendants of the slaves brought to the island from the West Africa. Yoruba is the largest ethnic community in Nigeria.

The Yoruba people that were brought to Cuba to work as slaves on the fields, could not reproduce the images, nor raise the temples of their gods (orishas). Consequently, they had to syncretize their saints with the Catholic cults, hiding their holy things in the barracks that were gradually transformed into temple houses where they could perform their rituals according to the Santería.

The collection consists of the colorful dresses (yellow is the dominant color) and full-size terracotta statues of the different Afro-Cuban deities that were mostly represented in African style. The world of the orishas is explained by the English-speaking guide.

There are also some activities related with the Santería, like dance performances. The necessary information is given on the notice board in the entrance hall.

The museum is unique in its kind on the world. Even though, it is managed by its own income, it charges more than the state-run museums, as it is slightly overpriced.