While climbing the stairs to the upper floor, the visitor will see one of the self-portraits of the painter, reflecting his emotional status.

During the restoration process mural paintings have been found throughout in all the rooms of the upper floor. It is believed that these murals have been painted by the 18th century Cuban religious artist José Nicolás de la Escalera and José Andrés Sánchez. The upper floor has three permanent exhibition rooms.

One of the rooms of upper floor is dedicated to multiple uses, such as temporary exhibitions of Cuban and foreign artists of different forms of art, conferences and video presentations about the life of the Ecuadorian painter, and celebrations of the most important dates in the history of Ecuador.

In the first permanent exhibition room the visitor will find the furniture, some crafts from Ecuador and some objects in pre-Columbian style that the painter brought with. The decorative objects, made of brass, in the shape of some animals and a ceramic vase in vivid colors are some pieces of the collection that you will see in this room. The second permanent exhibition room is the studio of the renowned painter where you can see a series of his paintings on the walls, made by acrylic paints. Most of them were made in Cuba and in most of them the face of a woman was portrayed. However, the most outstanding pieces of the painting collection are the portraits of Fidel Castro.

Guayasamín wanted to go to Cuba and make the portrait of Fidel Castro. In 1961 Fidel agreed to pose for the artist. However, Fidel could do it only for 15 minutes, as many people surrounded him and draw his attention. Guayasamín didn’t give up and he succeeded to make the portraits of his close friend Fidel in 1981 and 1986. Guayasamín painted Fidel Castro in numerous poses. One of the oil portraits of Fidel Castro in Casa Oswaldo Guayasamín was painted by the artist for the celebration of the 70th age of the leader in 1996 and the second in 1991. There is also the portrait of Raúl Castro Ruz (1986). The original desk of Guayasamín, on which the oil paint tubes and brushes are placed, stands in the center of the room.

The modest furniture in the bedroom is good preserved. The walls are covered by the works of the artist, but the most striking one is the oil painting with flower, resting on the easel. A tiger, catching a small animal in its mouth, is another interesting detail of the bedroom.