At the north side of the Plaza de San Francisco, there is the neoclassical building of the Lonja del Comercio, built in 1907. This place was chosen specially, as the localization was familiar to the merchants that met in the Lonja de Viveres (Food Market) which had been built close to the Customs House in 1878. It was the meeting place for the merchants where they examined the products and agreed in prices.

The growing economic activities in Cuba required the establishment of the joint-stock company Lonja del Comercio de La Habana, Thus, constructing a new building became necessary. The project belonged to the Spanish architect Tomás Mur that worked in collaboration with the Cuban architect José Toraya Sicre.  The contractor was the American Purdy & Henderson Company.

The concrete building has a steel structure. The sixth floor has been added later in 1939. During the restoration in 1996 much of the original was preserved, but some additions were also made, like the panoramic lifts. The building has an attic on the top floor that is separated from the façade by double glazing walls. The central atrium has a dome with a beautiful copper statue of the Mercury, God of the Commerce in Greek mythology. It is the reproduction of the one, done by the Flemish sculptor Giambologna (Giovanni da Bologna or Jean de Boulegne) in Florence, Italy in the 16th century.

Currently the building houses some commercial and diplomatic offices of foreign firms.